← AtlasMolecular targets
The 98 ADCs grouped by the 50 antigens they bind. Each box gives the eye-tissue target-expression rates (Human Cell Atlas detection, HPA bulk RNA) and every ADC against that target - ranked by ocular burden, so on-target expression can be read against observed ocular toxicity.
ERBB2
HER2
Receptor tyrosine kinase
12 ADCs42.8% mean ocular
Eye-tissue target expression
FOLR1
Folate receptor alpha (FRalpha / FOLR1)
GPI-anchored
5 ADCs13.6% mean ocular
Eye-tissue target expression
TACSTD2
Tumor-associated calcium signal transducer 2 (TROP-2)
TACSTD / EpCAM-TROP
5 ADCs10.4% mean ocular
Eye-tissue target expression
TNFRSF17
BCMA (B-cell maturation antigen)
TNF receptor superfamily
4 ADCs43.9% mean ocular
Eye-tissue target expression
CD19
CD19
Immunoglobulin superfamily
4 ADCs41.3% mean ocular
Eye-tissue target expression
EGFR
Epidermal growth factor receptor (EGFR; ErbB1/HER1)
Receptor tyrosine kinase
4 ADCs27.3% mean ocular
Eye-tissue target expression
CD22
CD22
Siglec
4 ADCs12.4% mean ocular
Eye-tissue target expression
F3
Tissue factor (coagulation factor III, CD142)
Other
3 ADCs41.3% mean ocular
Eye-tissue target expression
MET
Hepatocyte growth factor receptor (MET / c-MET)
Receptor tyrosine kinase
3 ADCs24% mean ocular
Eye-tissue target expression
MSLN
Mesothelin
GPI-anchored
3 ADCs15.7% mean ocular
Eye-tissue target expression
CLDN18
Claudin-18.2 (CLDN18.2)
Claudin / tight-junction
3 ADCs7.1% mean ocular
Eye-tissue target expression
ENPP3
ENPP3 (CD203c)
Ectonucleotidase
2 ADCs58% mean ocular
Eye-tissue target expression
NECTIN4
Nectin-4
Nectin / Ig-CAM
2 ADCs53% mean ocular
Eye-tissue target expression
CD70
CD70 (CD27 ligand / CD27L / TNFSF7)
TNF receptor superfamily
2 ADCs51.7% mean ocular
Eye-tissue target expression
SLC34A2
NaPi2b (sodium-dependent phosphate transport protein 2B)
SLC transporter
2 ADCs30.5% mean ocular
Eye-tissue target expression
TPBG
Trophoblast glycoprotein (5T4)
Other
2 ADCs24.3% mean ocular
Eye-tissue target expression
CD79B
CD79B
Immunoglobulin superfamily
2 ADCs24.1% mean ocular
Eye-tissue target expression
CEACAM5
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5 / CEA)
Nectin / Ig-CAM
2 ADCs19% mean ocular
Eye-tissue target expression
DLL3
Delta-like protein 3 (DLL3)
Notch ligand
2 ADCs1.7% mean ocular
Eye-tissue target expression
CD33
CD33
Siglec
2 ADCs0% mean ocular
Eye-tissue target expression
ADAM9
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)
Receptor tyrosine kinase
1 ADC77.8% mean ocular
Eye-tissue target expression
CCR7
C-C chemokine receptor type 7 (CCR7)
GPCR
1 ADC56.3% mean ocular
Eye-tissue target expression
MUC1
CanAg (CA242), a sialylated carbohydrate epitope on MUC1
Mucin
1 ADC50% mean ocular
Eye-tissue target expression
ALCAM
ALCAM (CD166)
Nectin / Ig-CAM
1 ADC49% mean ocular
Eye-tissue target expression
FGFR2
FGFR2
Receptor tyrosine kinase
1 ADC40% mean ocular
Eye-tissue target expression
MUC1 (CA6 epitope carried on MUC1)
CA6 sialoglycotope (MUC1-associated tumor carbohydrate antigen) -- NOTE: not carbonic anhydrase 6
Mucin
1 ADC36% mean ocular
Eye-tissue target expression
SLITRK6
SLIT and NTRK-like protein 6 (SLITRK6)
Other
1 ADC29% mean ocular
Eye-tissue target expression
LRRC15
LRRC15 (leucine-rich repeat-containing protein 15)
Other
1 ADC24.4% mean ocular
Eye-tissue target expression
CD276
B7-H3 (CD276)
Immunoglobulin superfamily
1 ADC19.8% mean ocular
Eye-tissue target expression
FGFR3
Fibroblast growth factor receptor 3
Receptor tyrosine kinase
1 ADC12% mean ocular
Eye-tissue target expression
VEGFA
Vascular endothelial growth factor A (VEGF-A)
Other
1 ADC10% mean ocular
Eye-tissue target expression
LY6E
Lymphocyte antigen 6E (LY6E)
GPI-anchored
1 ADC10% mean ocular
Eye-tissue target expression
EFNA4
Ephrin-A4
Receptor tyrosine kinase
1 ADC8% mean ocular
Eye-tissue target expression
SDC1
Syndecan-1 (CD138)
Other
1 ADC6.3% mean ocular
Eye-tissue target expression
SLC39A6
LIV-1 (Zinc transporter ZIP6 / SLC39A6)
Receptor tyrosine kinase
1 ADC5.9% mean ocular
Eye-tissue target expression
LY75
Lymphocyte antigen 75 (CD205 / DEC-205)
Other
1 ADC5.9% mean ocular
Eye-tissue target expression
TNFRSF8
CD30
TNF receptor superfamily
1 ADC5% mean ocular
Eye-tissue target expression
NOTCH3
Neurogenic locus notch homolog protein 3 (Notch3)
Notch ligand
1 ADC5% mean ocular
Eye-tissue target expression
NCAM1
NCAM1 (CD56)
Nectin / Ig-CAM
1 ADC4.7% mean ocular
Eye-tissue target expression
ERBB3
HER3
Receptor tyrosine kinase
1 ADC2.7% mean ocular
Eye-tissue target expression
IL2RA
CD25 (IL-2 receptor subunit alpha / IL2RA)
Cytokine receptor
1 ADC0.9% mean ocular
Eye-tissue target expression
CEACAM5; CEACAM6
N256-glycosylated CEACAM5 and CEACAM6 (shared tumor-specific glyco-epitope)
Nectin / Ig-CAM
1 ADC0% mean ocular
Eye-tissue target expression
CD46
Membrane cofactor protein (CD46)
Other
1 ADC0% mean ocular
Eye-tissue target expression
GPNMB
GPNMB
Other
1 ADC0% mean ocular
Eye-tissue target expression
GUCY2C
Guanylyl cyclase C (GCC)
Other
1 ADC0% mean ocular
Eye-tissue target expression
SEZ6
Seizure protein 6 homolog (SEZ6)
Other
1 ADC0% mean ocular
Eye-tissue target expression
CD74
HLA class II histocompatibility antigen gamma chain (CD74 / invariant chain / Ii)
Other
1 ADC0% mean ocular
Eye-tissue target expression
CLDN6
Claudin-6
Claudin / tight-junction
1 ADC0% mean ocular
Eye-tissue target expression
VTCN1
B7-H4 (B7x; B7S1; VTCN1)
Other
1 ADC0% mean ocular
Eye-tissue target expression
ROR1
ROR1
Receptor tyrosine kinase
1 ADC0% mean ocular
Eye-tissue target expression