ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
← Targets
Target

CD22

Gene
CD22
Siglec
UniProt · P20273 ↗ADCdb · TAR0XTCGM ↗
Target expression

Eye-tissue expression

Cornea · central
0.5 %
Cornea · limbal
1.1 %
Conjunctiva
1.64 %
RPE
1.16 %
Retina · HPA
0 nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
4 agents

ADCs against this target

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
TRPH-222Maytansine (maytansinoid derivative; ADCdb PAY0CHGPD)
31
9.1
Pinatuzumab vedotinMMAE
9.5
59
Moxetumomab pasudotoxPE38 (Pseudomonas exotoxin)
9
65
41
21
43
35
Inotuzumab ozogamicinCalicheamicin gamma1
0
71
94
98
94
31
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed