ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
Tissue factor (CD142)
Gene
F3
Cytokine receptor
UniProt · P13726 ↗
ADCdb · TAR0ZIMMG ↗
Target expression
Eye-tissue expression
Cornea · central
8.16
%
Cornea · limbal
21.91
%
Conjunctiva
66.36
%
RPE
51.39
%
Retina · HPA
67.1
nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
3 agents
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Tisotumab vedotin
MMAE
55
34
16
41
33
2
38
XB-002 (Samatatug zovodotin)
ZD02044 (zovodotin)
42
MRG-004A
MMAE
27
17
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed