ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
Neurogenic locus notch homolog protein 3 (Notch3)
Gene
NOTCH3
Notch ligand
UniProt · Q9UM47 ↗
ADCdb · TAR0PNBPC ↗
Target expression
Eye-tissue expression
Cornea · central
-
Cornea · limbal
-
Conjunctiva
-
RPE
-
Retina · HPA
-
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
1 agent
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
PF-06650808
Aur0101 (auristatin 0101; PF-06380101)
5
12.5
15
2.5
20
40
10
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed