ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
← Targets
Target

Nectin-4

Gene
NECTIN4
Nectin / Ig-CAM
UniProt · Q96NY8 ↗ADCdb · TAR0MWTFE ↗
Target expression

Eye-tissue expression

Cornea · central
71.38 %
Cornea · limbal
82.84 %
Conjunctiva
56.73 %
RPE
0.33 %
Retina · HPA
0 nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
2 agents

ADCs against this target

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
CRB-701 (SYS6002)Monomethyl auristatin E (MMAE)
66
27
18.9
21
18.9
8.4
Enfortumab vedotinMMAE
40
75
27
28
35
3
53
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed