ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
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Target

BCMA

Gene
TNFRSF17
TNF receptor superfamily
UniProt · Q02223 ↗ADCdb · TNFRSF17 ↗
Target expression

Eye-tissue expression

Cornea · central
0.4 %
Cornea · limbal
0.6 %
Conjunctiva
0.06 %
RPE
0 %
Retina · HPA
0.1 nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
4 agents

ADCs against this target

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Belantamab mafodotinCys-mcMMAF
92
88
52
100
51
32
26
MEDI2228SG3199 (PBD dimer)
53.7
24.4
31.7
AMG-224DM1 (mertansine / emtansine)
30
45.5
27.3
72.7
27.3
36.4
9.1
HDP-101HDP 30.2115 (alpha-amanitin derivative)
0
22
56
33
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed