ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
ALCAM (CD166)
Gene
ALCAM
Nectin / Ig-CAM
UniProt · Q13740 ↗
ADCdb · TAR0UPRHI ↗
Target expression
Eye-tissue expression
Cornea · central
5.87
%
Cornea · limbal
13.48
%
Conjunctiva
59.71
%
RPE
-
Retina · HPA
3.3
nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
1 agent
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Praluzatamab ravtansine
DM4 (free)
49
22.2
2
4
9.1
46.5
16.2
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed