ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
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Target

HER2

Gene
ERBB2
Receptor tyrosine kinase
UniProt · P04626 ↗ADCdb · TAR0THKZD ↗
Target expression

Eye-tissue expression

Cornea · central
46.2 %
Cornea · limbal
61.99 %
Conjunctiva
61.13 %
RPE
5.48 %
Retina · HPA
7.5 nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
12 agents

ADCs against this target

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
A166Duostatin-5
100
18.5
10.8
4.6
23.5
10.8
3.1
53.1
DP-303cMonomethyl auristatin E (MMAE)
94.7
31.9
14.9
26.6
4.3
46.8
Trastuzumab duocarmazineseco-DUBA
78.1
5.5
15.8
5.5
10.3
18.5
7.6
ZV0203Duostatin 5 (Duo-5/DUO5)
60
40
26.7
26.7
0
FS-1502MMAF (free)
55.3
66.7
34
26.7
33.3
3.3
ARX788pAF-AS269 catabolite
46.4
70.9
23.3
36.7
25
20
34.8
Zanidatamab zovodotin (ZW49)ZD02044
45
29
0
Trastuzumab deruxtecanDXd
11
67
70
52
64
76
11
13
PF-06804103Aur0101 (PF-06380101 / Aur-06380101; payload moiety 'pelidotin')
9.5
17.9
5.3
2.1
25.3
30.5
1.1
32.6
Trastuzumab emtansineLys-SMCC-DM1
5
98
39
83
60
40
1.2
21
Disitamab vedotinMMAE
5
42.1
42.1
24.3
21.5
29
68.2
Trastuzumab rezetecanRezetecan (SHR9265 / SHR169265)
3.3
42.9
79.4
42.9
76.2
79.4
11.6
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed