ADC TOXICITY ATLAS
Targets
Target

N256-glycosylated CEACAM5 and CEACAM6 (shared tumor-specific glyco-epitope)

Gene
CEACAM5; CEACAM6
Nectin / Ig-CAM
UniProt · P06731 (CEACAM5); P40199 (CEACAM6)ADCdb · TAR0CXRBX
Target expression

Eye-tissue expression

Cornea · central
-
Cornea · limbal
-
Conjunctiva
-
RPE
-
Retina · HPA
-
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
1 agent

ADCs against this target

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
EBC-129Monomethyl auristatin E (MMAE)
0
17
31
22
17
39
6
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed