ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
CD33
Gene
CD33
Siglec
UniProt · P20138 ↗
ADCdb · TAR0OVWVF ↗
Target expression
Eye-tissue expression
Cornea · central
0.07
%
Cornea · limbal
0.03
%
Conjunctiva
0.06
%
RPE
0.46
%
Retina · HPA
0.2
nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
2 agents
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Gemtuzumab ozogamicin
Calicheamicin gamma1
0
51
21
Vadastuximab talirine
SG3199 (PBD dimer)
0
5
18
44
38
34
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed