ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
CD25 (IL-2 receptor subunit alpha / IL2RA)
Gene
IL2RA
Cytokine receptor
UniProt · P01589 ↗
ADCdb · TAR0CYSHF ↗
Target expression
Eye-tissue expression
Cornea · central
-
Cornea · limbal
-
Conjunctiva
-
RPE
-
Retina · HPA
-
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
1 agent
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Camidanlumab tesirine
SG3199 (PBD dimer)
0.9
31.6
16.2
20.5
24.8
27.4
3.4
6.8
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed