Computed & derived values

The corneal, limbal, conjunctival, and RPE detection rates (hca_*) are the fraction of cells in which the target gene is detected in single-cell RNA-seq atlases of human ocular tissue, from the Human Cell Atlas. The retina value (hpa_retina_ntpm) is bulk retina expression in normalized transcripts per million (nTPM) from the Human Protein Atlas. Both are properties of the target gene, so they are shared across every ADC against the same target.

A value of 0% means the target was assessed and not detected in that tissue; a blank means the tissue was not assessed.

severity_ratio = grade-3+ rate ÷ any-grade rate (the fraction of ocular events that are severe). severity_weighted = 0.3 × any-grade + 0.7 × grade-3+ (a single composite weighting severe events more heavily). Both are computed from the reported ocular-AE rates, which carry their own primary sources.

A three-way provenance flag separating a true documented zero from missing data: reported (a measured ocular-AE rate > 0 at the recommended dose), documented-absent (the eye was assessed and explicitly clear - a real 0%), and unknown (never assessed; excluded from the Atlas).

Mechanistic subtype, Fcγ-receptor and C1q binding status, effector-silencing annotation, dose basis, linker symmetry, and the released-catabolite identity are inferred deterministically from the construct's composition (isotype, Fc mutations, linker/payload chemistry) rather than measured. The composition fields they derive from each link to their own public source.