ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
← Targets
Target

Delta-like protein 3 (DLL3)

Gene
DLL3
Notch ligand
UniProt · Q9NYJ7 ↗ADCdb · TAR0HELFC ↗
Target expression

Eye-tissue expression

Cornea · central
-
Cornea · limbal
-
Conjunctiva
-
RPE
-
Retina · HPA
-
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
2 agents

ADCs against this target

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
SC-002 (rovalpituzumab, DLL3, PBD/SG3199)SC-DR002 (PBD dimer warhead); ADCdb payload = SG3199 (PAY0LZRXU)
2.9
Rovalpituzumab tesirineSG3199 (PBD dimer)
0.5
13
9
22
11
24
1.9
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed