ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
Guanylyl cyclase C (GCC)
Gene
GUCY2C
Other
UniProt · P25092 ↗
ADCdb · TAR0ZYWVJ ↗
Target expression
Eye-tissue expression
Cornea · central
-
Cornea · limbal
-
Conjunctiva
-
RPE
-
Retina · HPA
-
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
1 agent
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Indusatumab vedotin
MMAE
0
28.6
25
17.9
39.3
52.6
0
10.5
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed