ADC TOXICITY ATLAS
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Target

TROP-2

Gene
TACSTD2
TACSTD / EpCAM-TROP
UniProt · P09758 ↗ADCdb · TAR0MIBZW ↗
Target expression

Eye-tissue expression

Cornea · central
65.43 %
Cornea · limbal
73.31 %
Conjunctiva
86.39 %
RPE
0 %
Retina · HPA
0 nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
5 agents

ADCs against this target

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Datopotamab deruxtecanDXd
38
24
30
35
56
2.4
PF-06664178Aur0101 (Auristatin 0101 / PF-06380101)
6.5
Sacituzumab govitecanSN-38
5
27
78
23
94
59
24
18
Sacituzumab tirumotecanKL610023 (also T030; belotecan-derived)
2.3
25
74
41
80
44
3
0
BAT-8008Exatecan
0
53.2
34.2
79.1
57.6
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed