ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
Mesothelin
Gene
MSLN
GPI-anchored
UniProt · Q13421 ↗
ADCdb · TAR0NEZUA ↗
Target expression
Eye-tissue expression
Cornea · central
13.34
%
Cornea · limbal
19.42
%
Conjunctiva
55.48
%
RPE
-
Retina · HPA
0.6
nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
3 agents
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Anetumab ravtansine
DM4 (free)
37
29
21
16
58
37
BMS-986148
Tubulysin (proprietary tubulysin analog)
10
49
32
DMOT4039A
MMAE
0
12
17
37
19
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed