ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
CEACAM5 (CEA)
Gene
CEACAM5
Nectin / Ig-CAM
UniProt · P06731 ↗
ADCdb · TAR0CXRBX ↗
Target expression
Eye-tissue expression
Cornea · central
0.03
%
Cornea · limbal
0.7
%
Conjunctiva
10.55
%
RPE
0
%
Retina · HPA
0
nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
2 agents
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Tusamitamab ravtansine
DM4 (free)
38
1.1
1.1
3.3
22.8
13
M-9140
Exatecan
0
12.5
42.5
35
57.5
12.5
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed