ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
CD19
Gene
CD19
Immunoglobulin superfamily
UniProt · P15391 ↗
ADCdb · TAR0EBTXG ↗
Target expression
Eye-tissue expression
Cornea · central
0
%
Cornea · limbal
0
%
Conjunctiva
0
%
RPE
0.05
%
Retina · HPA
0
nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
4 agents
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Denintuzumab mafodotin (NHL)
Cys-mcMMAF
84
29
Denintuzumab mafodotin (ALL)
Cys-mcMMAF
56
18
34
52
Coltuximab ravtansine
DM4 (free)
25
79
84
57
87
23
8
Loncastuximab tesirine
SG3199 (PBD dimer)
0
57
52
58
51
23
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed