ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Targets
Target
C-C chemokine receptor type 7 (CCR7)
Gene
CCR7
GPCR
UniProt · P32248 ↗
ADCdb · TAR0ZYPEF ↗
Target expression
Eye-tissue expression
Cornea · central
-
Cornea · limbal
-
Conjunctiva
-
RPE
-
Retina · HPA
-
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
1 agent
ADCs against this target
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
JBH-492
DM4 (ravtansine; mertansine DM4)
56.3
50
4
8
43
4
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed