ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
← Targets
Target

EGFR

Gene
EGFR
Receptor tyrosine kinase
UniProt · P00533 ↗ADCdb · TAR0UYFIF ↗
Target expression

Eye-tissue expression

Cornea · central
89.35 %
Cornea · limbal
97.58 %
Conjunctiva
93.02 %
RPE
83.36 %
Retina · HPA
9.4 nTPM
Computed · Human Cell Atlas (scRNA detection) & HPA bulk RNA - how this is computed →
4 agents

ADCs against this target

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Depatuxizumab mafodotinCys-mcMMAF
94
40.5
7.1
61
29.8
14.3
AVID-100Lys-SMCC-DM1
8
20
24
4
32
Serclutamab talirine (ABBV-321, EGFR, PBD/SGD-1882)SGD-1882 (PBD dimer)
7
21
18
5
18
2
Cetuximab saratolacanIRDye700DX
0
16.7
23.3
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed