ADC TOXICITY ATLAS
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Linker

SPDB / sulfo-SPDB

Cleavable

[H]c1nc(SSC([H])([H])C([H])([H])C([H])([H])C(=O)ON2C(=O)C([H])([H])C([H])([H])C2=O)c([H])c([H])c1[H]
Physicochemistry

Properties

MW
326.399 Da
TPSA
76.57 Ų
xLogP
2.2093
Formula
C13H14N2O4S2
Cleavage
Cleavable
Attachment
Lysine
9 agents

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Cantuzumab ravtansineMUC1
50
Praluzatamab ravtansineALCAM
49
22.2
2
4
9.1
46.5
16.2
Tusamitamab ravtansineCEACAM5
38
1.1
1.1
3.3
22.8
13
Anetumab ravtansineMSLN
37
29
21
16
58
37
SAR-566658MUC1 (CA6 epitope carried on MUC1)
36
Coltuximab ravtansineCD19
25
79
84
57
87
23
8
LY3076226 (IMC-D11)FGFR3
12
28
0
20
12
44
0
16
Indatuximab ravtansineSDC1
6.3
MEN-1309 (OBT076)LY75
5.9
41
41
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed