ADC TOXICITY ATLAS
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Linker

mc (non-cleavable)

Non-cleavable

O=C(O)CCCCCN1C(=O)C=CC1=O
Physicochemistry

Properties

MW
211.217 Da
TPSA
74.68 Ų
xLogP
0.5564
Formula
C10H13NO4
Cleavage
Non-cleavable
Attachment
Cysteine (interchain)
8 agents

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Depatuxizumab mafodotinEGFR
94
40.5
7.1
61
29.8
14.3
Belantamab mafodotinTNFRSF17
92
88
52
100
51
32
26
AGS-16C3FENPP3
85
7.6
35.3
29.4
55.9
8
Denintuzumab mafodotin (NHL)CD19
84
29
Vorsetuzumab mafodotinCD70
57
26
30
Denintuzumab mafodotin (ALL)CD19
56
18
34
52
PF-06263507TPBG
38.5
11.5
23.1
7.7
23.1
7.7
AGS-16M8FENPP3
31
30.8
30.8
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed