ADC TOXICITY ATLAS
Payloads & linkers
Payload

N/A (naked antibody)

structure not applicable
Physicochemistry

Properties

MW
-
XLogP3
-
logD₇.₄
-
TPSA
-
pKa
-
Charge pH 7.4
-
H-bond donors
-
H-bond acceptors
-
Bystander
-
PubChem CID
-
Bioactivity
Mechanism is payload-independent: farletuzumab is a naked anti-FRalpha mAb acting via ADCC, CDC, induction of autophagy, and inhibition of FRalpha-Lyn kinase growth signaling; it does not block folate binding/transport. No cytotoxic-payload IC50 applies.
1 agent

ADCs built on this payload

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Farletuzumab (naked Ab)FOLR1
0
25
51
33.3
42.4
16
19.6
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed