← Payloads & linkersCCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O
Physicochemistry
Properties
Bioactivity
Free payload SN-38 is a potent TOP1 (DNA topoisomerase I) inhibitor. ADCdb reports SN-38 IC50 values in the picomolar-to-low-nanomolar range across cell lines (e.g., Daudi 0.13 nM, Ramos 0.4 nM, Reh 0.47 nM). For the ADC sacituzumab govitecan, ADCdb cites cell-kill IC50 of ~0.18-