ADC TOXICITY ATLAS
Payloads & linkers
Payload · Other

PE38 (Pseudomonas exotoxin)

ADP-ribosyl. eEF2 (protein)

structure not applicable
Physicochemistry

Properties

MW
38000 Da
XLogP3
-
logD₇.₄
-
TPSA
-
pKa
-
Charge pH 7.4
-
H-bond donors
-
H-bond acceptors
-
Bystander
No
PubChem CID
-
Bioactivity
No molecular IC50/potency disclosed in ADCdb or PubChem. ADCdb reports clinical efficacy only: objective response rates ranging ~13% to 100% across trials/doses/indications (relapsed/refractory hairy cell leukemia and ALL). Mechanism: PE38 catalyzes ADP-ribosylation of eukaryotic
1 agent

ADCs built on this payload

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Moxetumomab pasudotoxCD22
9
65
41
21
43
35
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed