Payload · Amatoxin

HDP 30.2115 (alpha-amanitin derivative)

RNA polymerase II inhibitor (transcription inhibition; POLR2A poison)

CCC(C)C1NC(=O)CNCC2Cc3c([nH]c4ccccc34)SCC(NC(=O)CNCC1=O)C(=O)NC(CC(N)=O)C(=O)N1CC(O)CC1C(=O)NC(C(C)C(O)CO)C(=O)N2

Physicochemistry

Properties

919 Da

XLogP3

-4.4

logD₇.₄

TPSA

400 Å²

pKa

Charge pH 7.4

H-bond donors

H-bond acceptors

Bystander

Partial

PubChem CID

Bioactivity

ADCdb reports HDP-101 / HDP 30.2115 cytotoxicity IC50 across 11 cell-line experiments ranging from ~0.01 nM (highest potency, U266B1 myeloma line) to >1000 nM (non-target HS-5 and U2OS lines), demonstrating selective killing of BCMA-expressing multiple myeloma cells. Mechanism: a

1 agent

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

HDP-101TNFRSF17

0%severity100%

Assessed · clear

true 0%

No data

never assessed