Payload · Taxane

Paclitaxel

Microtubule stabilizer / tubulin inhibitor (antimitotic)

CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C

Physicochemistry

Properties

853.9 Da

XLogP3

2.5

logD₇.₄

TPSA

221 Å²

pKa

Charge pH 7.4

H-bond donors

H-bond acceptors

Bystander

PubChem CID

36314

Bioactivity

Payload paclitaxel: microtubule-stabilizing taxane (binds beta-tubulin, blocks microtubule depolymerization; ADCdb therapeutic target Microtubule PATR0CXRBX). Bevacizumab binds/neutralizes VEGF-A. No discrete IC50/binding affinity values reported on the ADCdb AB-160 page. Phase I

1 agent

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

AB-160VEGFA

100

0%severity100%

Assessed · clear

true 0%

No data

never assessed