Payload · Auristatin

Auristatin F-HPA (AF-HPA)

Tubulin inhibitor (microtubule)

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NCCCO)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C

Physicochemistry

Properties

803.1 Da

XLogP3

4.3

logD₇.₄

TPSA

170 Å²

pKa

Charge pH 7.4

H-bond donors

H-bond acceptors

Bystander

Yes

PubChem CID

71135741

Bioactivity

ADCdb (DRG0OZSZX) reports in vitro EC50 0.52 nM in OVCAR-3 (NaPi2b+ ovarian) cells; clinical ORR 34% overall and 35% in SLC34A2/NaPi2b-high tumors. Payload AF-HPA is a tubulin/microtubule-targeting auristatin (target mechanism listed as Microtubule).

1 agent

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

Upifitamab rilsodotinSLC34A2

0%severity100%

Assessed · clear

true 0%

No data

never assessed