Payload · Auristatin

Auristatin W

Tubulin inhibitor

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N4CCCCO4)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC

Physicochemistry

Properties

746 Da

XLogP3

2.6

logD₇.₄

1.5

TPSA

158 Å²

pKa

3.5

Charge pH 7.4

Zwitterion

H-bond donors

H-bond acceptors

Bystander

PubChem CID

86678408

Bioactivity

Auristatin W is a microtubule-inhibiting auristatin (dolastatin-10 analog); ADCdb lists payload mechanism as 'Microtubule (MT)' disruption. No discrete payload IC50 reported on ADCdb/PubChem. Clinically (first-in-human phase I, PMID 31502117) the ADC was terminated for poor toler

1 agent

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

Aprutumab ixadotinFGFR2

0%severity100%

Assessed · clear

true 0%

No data

never assessed