ADC TOXICITY ATLAS
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Payload · PBD dimer
SG3199 (PBD dimer)
DNA cross-linker
CC1=CN2[C@@H](C1)C=NC3=CC(=C(C=C3C2=O)OC)OCCCCCOC4=C(C=C5C(=C4)N=C[C@@H]6CC(=CN6C5=O)C)OC
Physicochemistry
Properties
MW
584.7
Da
XLogP3
2.8
logD₇.₄
2.5
TPSA
102
Ų
pKa
5
Charge pH 7.4
0
H-bond donors
0
H-bond acceptors
8
Bystander
Partial
PubChem CID
90132565
Bioactivity
SG3199 is a sequence-selective DNA minor-groove interstrand crosslinking PBD dimer; ADCdb lists its molecular target as human DNA (hDNA). No numeric IC50 reported on the ADCdb ADC page or the PubChem record.
5 agents
ADCs built on this payload
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
MEDI2228
TNFRSF17
53.7
24.4
31.7
SC-002 (rovalpituzumab, DLL3, PBD/SG3199)
DLL3
2.9
Camidanlumab tesirine
IL2RA
0.9
31.6
16.2
20.5
24.8
27.4
3.4
6.8
Rovalpituzumab tesirine
DLL3
0.5
13
9
22
11
24
1.9
Loncastuximab tesirine
CD19
0
57
52
58
51
23
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed