Bioactivity
ADCdb lists T-DM1 cellular IC50 values spanning ~0.04 nM (high HER2-expressing lines) to >500 nM (low/negative HER2 lines), HER2-expression dependent. No isolated free-payload (DM1) IC50 is given on the ADCdb ADC page; DM1 is a potent antimitotic maytansinoid that inhibits tubuli