Payload · Microtubule (other)

Eribulin

Tubulin inhibitor

C[C@@H]1C[C@@H]2CC[C@H]3C(=C)C[C@@H](O3)CC[C@]45C[C@@H]6[C@H](O4)[C@H]7[C@@H](O6)[C@@H](O5)[C@@H]8[C@@H](O7)CC[C@@H](O8)CC(=O)C[C@H]9[C@H](C[C@H](C1=C)O2)O[C@@H]([C@@H]9OC)C[C@@H](CN)O

Physicochemistry

Properties

729.9 Da

XLogP3

1.1

logD₇.₄

TPSA

146 Å²

pKa

Charge pH 7.4

H-bond donors

H-bond acceptors

Bystander

Yes

PubChem CID

11354606

Bioactivity

ADCdb reports ADC cytotoxicity IC50: IGROV-1 (ovarian) 0.01 pM / 0.02 nM; NCI-H2110 (lung) 0.74 pM / 0.42 nM; Caov-3 (ovarian) 0.43 nM; OVCAR-3 (ovarian) 0.75 nM (FOLR1-dependent, sub-nM to pM potency).

1 agent

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

Farletuzumab ecteribulinFOLR1

20.8

33.3

6.7

0%severity100%

Assessed · clear

true 0%

No data

never assessed