ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
← Payloads & linkers
Payload · Topoisomerase I inhibitor

YL0010014

DNA topoisomerase 1 (TOP1) inhibition

CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC6=C(C=C5N=C4C3=C2)OCO6)CCCO)O
Physicochemistry

Properties

MW
450.4 Da
XLogP3
0.7
logD₇.₄
-
TPSA
118 Ų
pKa
-
Charge pH 7.4
0
H-bond donors
2
H-bond acceptors
8
Bystander
Yes
PubChem CID
164872962
Bioactivity
Payload YL0010014 is a DNA topoisomerase 1 (TOP1) inhibitor (per ADCdb payload PAY0HNGJG mechanism field); it is a camptothecin/FL118-class warhead (10,11-methylenedioxy-camptothecin scaffold with 3-hydroxypropyl substituent). No numeric IC50 reported on the ADCdb ADC or payload
1 agent

ADCs built on this payload

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
XNW-27011CLDN18
0
67.9
59.5
0
0
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed