ADC TOXICITY ATLAS
Payloads & linkers
Payload · Calicheamicin

N-acetyl-gamma-calicheamicin

DNA double-strand break induction (enediyne DNA-damaging agent)

CCN([C@H]1CO[C@H](C[C@@H]1OC)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C#C/C=C\C#C[C@@]4(CC(=O)C(=C3C4=CCSSSC)NC(=O)OC)O)C)NO[C@H]5C[C@@H]([C@@H]([C@H](O5)C)SC(=O)C6=C(C(=C(C(=C6OC)OC)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)OC)O)I)C)O)O)C(=O)C
Physicochemistry

Properties

MW
1410.4 Da
XLogP3
2
logD₇.₄
-
TPSA
418 Ų
pKa
-
Charge pH 7.4
0
H-bond donors
7
H-bond acceptors
27
Bystander
Partial
PubChem CID
134819845
Bioactivity
ADCdb payload page (PAY0GKVJX) reports payload potency IC50 = 112 pmol/L (0.112 nM) in HEK-293T cells. Payload mechanism: enediyne that, after trisulfide reduction/Bergman-type cyclization, generates a diradical inducing DNA double-strand breaks.
1 agent

ADCs built on this payload

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
SC-011 / ABBV-011 (SC17, SEZ6, calicheamicin)SEZ6
0
35
40
15
45
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed