Payload · Maytansinoid

DM21 (linker-payload DM21-C)

Microtubule inhibitor (tubulin polymerization inhibitor; antimitotic)

C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCCCCS)C)\C)OC)(NC(=O)O2)O

Physicochemistry

Properties

780.4 Da

XLogP3

3.3

logD₇.₄

TPSA

157 Å²

pKa

Charge pH 7.4

H-bond donors

H-bond acceptors

Bystander

Yes

PubChem CID

162623843

Bioactivity

IMGC936 is a next-generation maytansinoid ADC; the maytansinoid payload inhibits tubulin polymerization/microtubule assembly (anti-mitotic). The protease-released catabolites DM51 and DM50 are membrane-permeable and drive bystander killing. ADCdb assigns the payload therapeutic t

1 agent

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

0%severity100%

Assessed · clear

true 0%

No data

never assessed