← Payloads & linkersCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)NS(=O)(=O)C2=CC=C(C=C2)N)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C
Physicochemistry
Properties
Bioactivity
ADC cytotoxicity IC50 = 56 pmol/L (95% CI 48-65) in TF-expressing A431 cells; in vivo, XB002 produced complete tumor regressions in cervical and head/neck cancer PDX models with durable responses at a single 10 mg/kg dose. Payload ZD02044 is a tubulin-polymerization inhibitor (mi