Payload · Auristatin

Duostatin-5

Tubulin inhibitor

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=C(C=C2)N)CN=[N+]=[N-])OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C

Physicochemistry

Properties

772 Da

XLogP3

5.5

logD₇.₄

TPSA

161 Å²

pKa

Charge pH 7.4

H-bond donors

H-bond acceptors

Bystander

PubChem CID

138320017

Bioactivity

No payload-level IC50 reported by PubChem or ADCdb. Duostatin-5 is a microtubule-disrupting MMAF-derived auristatin. ADC clinical efficacy (A166/trastuzumab botidotin): ORR 73.90% at 4.8 mg/kg and partial-response rate ~25.92% in Phase 1 (per ADCdb DRG0TIZXC).

2 agents