Payload · Photosensitizer

IRDye700DX

Photochemical (690 nm NIR ROS)

C[Si](C)(CCC[N+](CCCS(=O)(=O)[O-])(CCCS(=O)(=O)[O-])CCCS(=O)(=O)[O-])O[Si]1(N2C3=C4C=CC=CC4=C2N=C5C6=C(C=CC=C6OCCCOC(=O)NCCCCCC(=O)ON7C(=O)CCC7=O)C(=N5)N=C8N1C(=NC9=NC(=N3)C1=CC=CC=C19)C1=CC=CC=C18)O[Si](C)(C)CCC[N+](CCCS(=O)(=O)[O-])(CCCS(=O)(=O)[O-])CCCS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+]

Physicochemistry

Properties

1954.2 Da

XLogP3

logD₇.₄

-5

TPSA

606 Å²

pKa

Charge pH 7.4

-4

H-bond donors

H-bond acceptors

Bystander

PubChem CID

102004325

Bioactivity

ADCdb payload page (PAY0EJBOG) reports no direct free-payload IC50; it cites EC50 values for an unrelated EGFR-PIT conjugate (ARB102-IR700), not cetuximab-saratolacan: LoVo 0.12 ug/mL, SW480 49.00 ng/mL, SNU-C1 74.00 ng/mL, AsPC-1 86.00 ng/mL. Mechanism: IRDye700DX is a silicon-p

1 agent

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

Cetuximab saratolacanEGFR

16.7

23.3

0%severity100%

Assessed · clear

true 0%

No data

never assessed