Payload · Maytansinoid

Maytansine (maytansinoid derivative; ADCdb PAY0CHGPD)

Microtubule/tubulin polymerization inhibitor (antimitotic, M-phase arrest)

C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4(C1O4)C)OC(=O)[C@H](C)NC)C)\C)OC)(NC(=O)O2)O

Physicochemistry

Properties

650.17 Da

XLogP3

3.28

logD₇.₄

TPSA

148.19 Å²

pKa

Charge pH 7.4

H-bond donors

H-bond acceptors

Bystander

PubChem CID

90167111

Bioactivity

ADCdb (DRG0JCWGF): Phase 1 objective response rate 22.70% (all). Preclinical xenograft tumor growth inhibition approximately 51% to 100% across cell lines. No payload IC50 reported on ADCdb/PubChem pages.

1 agent

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

TRPH-222CD22

9.1

0%severity100%

Assessed · clear

true 0%

No data

never assessed