Payload · PBD dimer

SG3199 (PBD dimer)

DNA cross-linker

COC1=CC=C(C=C1)C2=CN3[C@@H](C2)C=NC4=CC(=C(C=C4C3=O)OC)OCCCOC5=C(C=C6C(=C5)N=C[C@@H]7CC(=CN7C6=O)C8=CC=C(C=C8)N)OC

Physicochemistry

Properties

584.7 Da

XLogP3

2.8

logD₇.₄

2.5

TPSA

102 Å²

pKa

Charge pH 7.4

H-bond donors

H-bond acceptors

Bystander

Partial

PubChem CID

45257190

Bioactivity

ADCdb reports IC50 ~0.10 ng/mL in high-CD33-expressing AML cell lines (e.g., MV4-11) and primary AML samples, rising to >110 ng/mL (up to >5000 ng/mL) in CD33-low/negative lines, indicating CD33 target-dependent cytotoxicity. PBD-dimer payload acts as a DNA minor-groove cross-lin

2 agents

ADCs built on this payload

Agent · target

Ocular

Hepatic

Neutrop.

Thrombo.

Anemia

ILD

Neuro.

Serclutamab talirine (ABBV-321, EGFR, PBD/SGD-1882)EGFR

Vadastuximab talirineCD33

0%severity100%

Assessed · clear

true 0%

No data

never assessed