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Linker · Peptide

Plasma-stable valine-alanine (Val-Ala) dipeptide linker (site-specific; distinct from Rova-T tesirine/SG3249)

Cleavable

structure not applicable
Physicochemistry

Properties

MW
-
TPSA
-
xLogP
-
Formula
-
Cleavage
Cleavable
Attachment
Site-specific (engineered Cys)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
SC-002 (rovalpituzumab, DLL3, PBD/SG3199)DLL3
2.9
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed