ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker · Thioether (non-cleavable)
MCC (4-[N-maleimidomethyl]cyclohexane-1-carboxylate; SMCC-type)
Non-cleavable
structure not applicable
Physicochemistry
Properties
MW
-
TPSA
-
xLogP
-
Formula
-
Cleavage
Non-cleavable
Attachment
Lysine
1 agent
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
AMG-224
TNFRSF17
30
45.5
27.3
72.7
27.3
36.4
9.1
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed