ADC TOXICITY ATLAS
AtlasPayloads and LinkersPayloadsTargetsMethods
← Payloads & linkers
Linker

Cys-12 ADC linker (non-cleavable DBCO-maytansinoid)

Non-cleavable

CCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc21
Physicochemistry

Properties

MW
508.615 Da
TPSA
86.33 Ų
xLogP
2.9157
Formula
C29H36N2O6
Cleavage
Non-cleavable
Attachment
Site-specific (enzymatic/non-natural AA)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
STRO-001CD74
0
0
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed