ADC TOXICITY ATLAS
Payloads & linkers
Linker

CL2A (hydrazone+carbonate)

Cleavable

[H]OC([H])([H])c1c([H])c([H])c(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])OC([H])([H])C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])n2nnc(C([H])([H])N([H])C(=O)C3([H])C([H])([H])C([H])([H])C([H])(C([H])([H])N4C(=O)C([H])=C([H])C4=O)C([H])([H])C3([H])[H])c2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])c([H])c1[H]
Physicochemistry

Properties

MW
1062.229 Da
TPSA
313.81 Ų
xLogP
-0.3639
Formula
C50H79N9O16
Cleavage
Cleavable
Attachment
Cysteine (interchain)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Sacituzumab govitecanTACSTD2
5
27
78
23
94
59
24
18
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed