ADC TOXICITY ATLAS
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Linker

Sulfonyl pyrimidine-CL2A-carbonate (ADCdb: Pyrimidine-CL2A-carbonate)

Cleavable

NCCCCC(NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCn1cc(NC(=O)CCCC#Cc2cncnc2)nn1)C(=O)Nc1ccc(CO)cc1
Physicochemistry

Properties

MW
1001.149 Da
TPSA
302.21 Ų
xLogP
0.239
Formula
C47H72N10O14
Cleavage
Cleavable
Attachment
Cysteine (interchain)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Sacituzumab tirumotecanTACSTD2
2.3
25
74
41
80
44
3
0
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed