ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker
NH2-PEG3-Val-Cit-PABC
Cleavable
CC(C)[C@H](NC(=O)COCCOCCOCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc1ccc(CO)cc1
Physicochemistry
Properties
MW
568.67
Da
TPSA
216.36
Ų
xLogP
-0.8
Formula
C26H44N6O8
Cleavage
Cleavable
Attachment
Site-specific (enzymatic/non-natural AA)
2 agents
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
DP-303c
ERBB2
94.7
31.9
14.9
26.6
4.3
46.8
CRB-701 (SYS6002)
NECTIN4
66
27
18.9
21
18.9
8.4
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed