ADC TOXICITY ATLAS
Payloads & linkers
Linker

Cys-11 ADC linker (hydrophilic peptide-maleimide)

Cleavable

CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)CC(=O)N(C)Cc1cc(NC(=O)C(C)NC(=O)C(NC(=O)CCCCCN2C(=O)C=CC2=O)C(C)C)ccc1CO
Physicochemistry

Properties

MW
1282.465 Da
TPSA
368.32 Ų
xLogP
-4.1894
Formula
C59H91N15O17
Cleavage
Cleavable
Attachment
Cysteine (interchain)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Rinatabart sesutecanFOLR1
0
70
0
0
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed