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Linker

Mc-Val-Cit (maleimidocaproyl-valine-citrulline)

Cleavable

[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])=C([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])[H]
Physicochemistry

Properties

MW
467.523 Da
TPSA
188 Ų
xLogP
-0.3695
Formula
C21H33N5O7
Cleavage
Cleavable
Attachment
Cysteine (interchain)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
BMS-986148MSLN
10
49
32
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed