ADC TOXICITY ATLAS
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Linker

Mc-Ala-Ala-Ala (DM21-C linker)

Cleavable

C[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCCCCN1C(=O)C=CC1=O)C(=O)O
Physicochemistry

Properties

MW
424.454 Da
TPSA
161.98 Ų
xLogP
-0.9295
Formula
C19H28N4O7
Cleavage
Cleavable
Attachment
Site-specific (other)
1 agent

ADCs built on this linker

Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
IMGC-936ADAM9
77.8
7.7
0
10
38.5
23.1
15.4
0
0%severity100%
0
Assessed · clear
true 0%
No data
never assessed