ADC TOXICITY ATLAS
Atlas
Payloads and Linkers
Payloads
Targets
Methods
← Payloads & linkers
Linker · Cleavable
Dolaflexin (Fleximer/PHF polyacetal polymer; mal-(BA-EG2)-AF-HPA-Ala)
Cleavable
structure not applicable
Physicochemistry
Properties
MW
-
TPSA
-
xLogP
-
Formula
-
Cleavage
Cleavable
Attachment
Cysteine (interchain)
1 agent
ADCs built on this linker
Any-grade
Grade 3+
Agent · target
Ocular
Hepatic
Neutrop.
Thrombo.
Anemia
GI
ILD
Neuro.
Upifitamab rilsodotin
SLC34A2
41
69
49.6
39.2
51.9
9.6
0%
severity
100%
0
Assessed · clear
true 0%
No data
never assessed